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KMID : 0895820180280020061
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Journal of Oriental Rehabilitation Medicine
2018 Volume.28 No. 2 p.61 ~ p.72
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DRF and Single Dose Oral Toxicity Study of ChondroT in Rat
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Lim Young-Ha
Jeong Ji-Won
Kim Sun-Gil
Kim Ji-Hoon
Kim Seon-Jong
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Abstract
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Objectives: The purpose of this experiment is to evaluate 4 weeks DRF (Dose Rate Finding) and single oral dose toxicity of ChondroT in rats.
Methods: In 4-week DRF, male and female Sprague-Dawely rats were treated with ChondroT at oral dose of 0, 500, 1000, and 2000 mg/kg. clinical signs, body weight, food consumption, necropsy findings, organ weight, hematological and blood-chemical parameters, and histological findings were monitored for 4 weeks. Also, after single oral administration of ChondroT, mortality, clinical signs, body weight, and necropsy findings were minitored for 2 weeks.
Results: In 4-week DRF and single dose oral toxicity study of ChondroT in sprague-Dawley rats, ChondroT did not exhibit any toxicity under the study conditions employed.
Conclusions: The results suggested a no-observed adverse effects level (NOAEL) was over 2,000 mg/kg/day in SD rats after oral administration, this study could be used as basic study of the repeated dose 13-week oral toxicity study of ChondroT.
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KEYWORD
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ChondroT, Dose Rate Finding, Single Dose Toxicity
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